Fig. 6: P granules promote piRNA-targeting fidelity. | Nature Communications

Fig. 6: P granules promote piRNA-targeting fidelity.

From: GLH/VASA helicases promote germ granule formation to ensure the fidelity of piRNA-mediated transcriptome surveillance

Fig. 6

Model showing the P granule working in concert with Z and Mutator granules to maintain an environment that protects specific self genes from silencing and promotes the silencing of specific non-self genes (Left). In GLH/VASA mutants where granule integrity is lost, hundreds of typically expressed transcripts become targeted by PRG-1 and silencing machinery while hundreds of typically silenced transcripts become dispersed into the cytoplasm and expressed (Right).

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