Table 1 Genome-wide significant associations of SNPs with PA in the discovery cohort

From: Identification of risk loci for primary aldosteronism in genome-wide association studies

      

All

Men

 

Women

 

APA

 

BAH

 

SNP

chr

position

A1/A2

Freq

OR (CI)

P value

OR (CI)

P value

OR (CI)

P value

OR (CI)

P value

OR (CI)

P value

rs284277

1

10790797

C/A

0.38

1.62 (1.38–1.9)

3.22E-09**

1.8 (1.47–2.21)

1.09E-08**

1.35 (1.04–1.76)

0.0252

1.6 (1.33–1.94)

1.22E-06

1.61 (1.3–1.99)

1.28E-05

rs6679531

1

48524180

C/T

0.36

1.41 (1.2–1.65)

3.28E-05

1.1 (0.9–1.35)

0.350

2.14 (1.63–2.81)

5.25E-08**

1.41 (1.16–1.71)

0.000613

1.41 (1.14–1.75)

0.00188

rs2137320

11

1884342

A/G

0.42

1.51 (1.29–1.77)

1.92E-07*

1.36 (1.12–1.66)

0.00237

1.82 (1.41–2.37)

6.04E-06

1.74 (1.44–2.11)

1.18E-08**

1.3 (1.05–1.61)

0.0159

rs1535532

13

32114398

T/C

0.63

1.66 (1.41–1.95)

5.76E-10**

2.15 (1.74–2.66)

1.31E-12**

1.13 (0.87–1.46)

0.360

1.46 (1.21–1.77)

0.000107

1.98 (1.58–2.49)

3.88E-09**

rs5905587

X

43833996

C/T

0.64

1.6 (1.4–1.82)

7.79E-12**

1.59 (1.37–1.86)

2.31E-09**

1.67 (1.26–2.21)

0.000382

1.56 (1.32–1.84)

1.89E-07*

1.66 (1.38–1.99)

8.69E-08*

  1. Lead variants with a significant or a suggestive association with the phenotype in the full discovery cohort and/or in at least one stratified analysis are presented. Associations were tested using a logistic regression model in PLINK 1.9. **significant association after Bonferroni correction (P < 7.36 × 10−8) indicated in bold, *suggestive association (P < 10−6); position: genome build 37.
  2. A1 risk allele, A2 second allele, Freq risk allele frequency, OR (CI) odds ratio (95% confidence interval).
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