Table 1 Antibacterial activity of compounds 1–9, 15, and 21–27 (MIC and MBC values, μg/mL)a

From: Chimeric natural products derived from medermycin and the nature-inspired construction of their polycyclic skeletons

Compound

SA ATCC 6538

MRSA ATCC 43300

MRSE ATCC 35984

MIC

MBC

MIC

MBC

MIC

MBC

b

c

b

c

b

c

b

c

b

c

b

c

1

32

64

>64

>64

16

32

>64

>64

16

64

>64

>64

9

0.25

1

2

8

0.125

0.5

4

8

0.25

1

1

16

23

2

2

16

32

1

1

16

16

1

2

16

32

24

2

4

16

32

1

1

16

16

1

4

16

32

26

0.5

0.25

0.5

1

0.25

0.25

4

2

0.5

0.5

1

8

27

2

4

2

4

1

2

2

4

1

4

2

8

Ciprofloxacin

2

4

4

8

8

8

16

64

4

8

4

16

Vancomycin

1

1

1

16

2

2

8

16

2

2

4

32

  1. aCompounds 2–8, 15, 21, 22, and 25 did not show antibacterial activity against the three Gram-positive bacteria (Staphylococcus aureus ATCC 6538, methicillin-resistant Staphylococcus aureus subsp. aureus ATCC 43300, methicillin-resistant Staphylococcus epidermidis ATCC 35984) (MIC > 64 μg/mL). None of the tested compounds showed activity against the Gram-negative bacteria (Pseudomonas aeruginosa ATCC 10145 and Escherichia coli ATCC 11775) or fungi tested (Candida albicans ATCC 10231 and Candida glabrata ATCC 2001) (MIC > 64 μg/mL).
  2. bActivity was examined without BSA.
  3. cActivity was examined in the presence of 4% BSA.
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