Fig. 4: Spatial organization and signal processing in dual input model prototissues.
From: Signal processing and generation of bioactive nitric oxide in a model prototissue
Six different three-layer sequence arrangements of enzyme-CV hydrogel modules (case I (standard configuration; alternative configurations (cases XI-XV)) operating under dual substrate inputs are shown. Outputs in the interior lumen include NO (I and XII), H2O2 (XIII), or mixtures of H2O2 and NO (XIV and XV), depending on how the spatial sequence influences enzyme-mediated processing within the tubular micro-reactor. No outputs in the lumen are recorded for case XI. Labels and column representations are as shown in Fig. 3h. Reaction conditions: Glu (50 mM); Hu (6 mM); GOx (GOx-CV layer, 0.2 mg mL−1); HRP (HRP-CV layer, 0.2 mg mL−1); CAT (CAT-CV layer, 0.1 mg mL−1).
