Fig. 3: Patterning of intra- and inter-chromosomal contacts.
From: Deciphering multi-way interactions in the human genome
a Incidence matrix visualization of Chromosome 22 in adult fibroblasts. The numbers in the left column represent genomic loci at 1 Mb resolution. Each vertical line represents a multi-way contact, in which the nodes indicate the corresponding locus' participation in this contact. b Frequencies of Pore-C contacts in Chromosome 22. Bars are colored according to the order of contact. Blue, green, orange, and red correspond to 2-way, 3-way, 4-way, and 5-way contacts. c The most common 2-way, 3-way, 4-way, and 5-way intra-chromosome contacts within Chromosome 22 are represented as motifs, color-coded similarly to (b). d Zoomed in incidence matrix visualization in 100 kb resolution shows the multi-way contacts between three 1 Mb loci: L19 (blue), L21 (yellow), and L22 (red). An example 100 kb resolution multi-way contact is zoomed to read-level resolution. e Hypergraph representation of the 100 kb multi-way contacts from (d). Blue, yellow, and red labels correspond to loci L19, L21, and L22, respectively. f Incidence matrix visualization of the inter-chromosomal multi-way contacts between Chromosome 20 (orange) and Chromosome 22 (green) in 1 Mb resolution. Within this figure, all data are from one adult fibroblast sequencing run (V2) and multi-way contacts were determined after noise reduction at 1 Mb or 100 kb resolution accordingly (see Hypergraphs and Hypergraph Filtering in Methods).
