Fig. 7: Example transcription clusters.
From: Deciphering multi-way interactions in the human genome
Six examples of transcription clusters are shown for neonatal fibroblasts (left), adult fibroblasts (center), and B lymphocytes (right) as multi-way contacts (hypergraph motifs). Black labels indicate genes and chromosomes (bold). Red labels correspond to transcription factors shared between the majority of genes within the transcription cluster. For three-way contacts (green motifs), we highlight the transcription clusters' biological analog (blue-shaded box), showing how fragments of chromatin fold and congregate at a common transcription cluster (grey sphere). Each node (black dot) of the hyperedge and its denoted chromosome and gene in the hypergraph motif corresponds to a single chromatin fragment, colored according to chromosome, in the biological analog. Thus, a three-way hyperedge is depicted by three chromatin fragments in close spatial proximity. Multi-way contacts used for adult and neonatal fibroblasts include all experiments (V1-V4). Examples were selected from the subset of multi-way contacts summarized in the "Clusters with Common TFs'' column of Table 1.
