Fig. 1: Magnitude of anti-SARS-CoV-2 T cell and IgG responses measured in venous blood samples. | Nature Communications

Fig. 1: Magnitude of anti-SARS-CoV-2 T cell and IgG responses measured in venous blood samples.

From: Magnitude of venous or capillary blood-derived SARS-CoV-2-specific T cell response determines COVID-19 immunity

Fig. 1

a SARS-CoV-2-specific IFN-γ+ T cell responses were measured using the venous whole blood assay and sub-divided based on participant vaccination and prior SARS-CoV-2 (PCR and/or lateral flow test confirmed) infection status. ‘Vac + /Inf + ’ n = 60 (green), ‘Vac + /Inf-’ n = 82 (blue), ‘Vac-/Inf + ’ n = 4 (yellow), ‘Vac-/Inf-’ n = 1 (not plotted). SARS-CoV-2-specific IgG-binding responses targeting nucleocapsid (‘N’) (b; ****P < 0.0001, **P = 0.0016), spike receptor binding domain (‘RBD’) (c; **P = 0.0022, *P < 0.015), spike subunit 1 (‘S1’) (d; ***P = 0.0005, *(Vac + /Inf+ vs. Vac + /Inf-) P = 0.022, *(Vac-/Inf+ vs. Vac + /Inf-) P = 0.012) and spike subunit 2 (‘S2’) (e) were measured using the venous whole blood assay and sub-divided based on participant vaccination and prior SARS-CoV-2 (PCR and/or lateral flow test confirmed) infection status. ‘Vac + /Inf + ’ n = 60 (green), ‘Vac + /Inf-’ n = 71-82 (blue), ‘Vac-/Inf + ’ n = 4 (yellow). Comparisons used Kruskal-Wallis tests with correction for multiple comparisons using Dunn’s tests. Data are presented as box plots (centre line at the median, upper bound at 75th percentile, lower bound at 25th percentile) with whiskers at minimum and maximum values. Each dot represents one donor. Source data are provided as a Source Data file.

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