Fig. 3: SARS-CoV-2-specific T-cell responses. | Nature Communications

Fig. 3: SARS-CoV-2-specific T-cell responses.

From: Heterologous vector versus homologous mRNA COVID-19 booster vaccination in non-seroconverted immunosuppressed patients: a randomized controlled trial

Fig. 3

a Representative ex vivo IFN-γ ELISpot result from peripheral blood mononuclear cells (PBMCs) stimulated or not (neg, n = 4) with phytohemagglutinin (PHA, n = 1) or spike subunit S1 and S2 peptide pools (S1, S2, n = 2 for each) shown for one healthy control (HC) and one patient before and after booster vaccination. Bar graphs show mean spot-forming cells (SFCs) per 106 PBMCs. Dots represent individual replicates. b Composite ELISpot results from prepandemic controls (n = 5), vaccinated HC (n = 10), and patients before (pre, n = 41) and 1 week after (post, n = 46) third vaccination with vector and mRNA vaccine. Circles show sum of total responses from S1 and S2 peptide pools. Vertical lines indicate the mean. Paired Wilcoxon test was used to compare samples before and after booster vaccination. Mann–Whitney-U test was utilized to compare cellular vaccine responses. All tests were two-sided and no correction for multiple testing was performed. Source data are provided as a Source Data file.

Back to article page