Fig. 3: Inhibition of either 5th-LaN or its postsynaptic partners DN2s reduces light avoidance.
From: Circuit analysis reveals a neural pathway for light avoidance in Drosophila larvae
a The effect of Kir2.1-mediated silencing of clock neuron subsets on light avoidance at 550 lux. Silencing of the 5th-LaN or DN2s&Pdf-LaNs results in defective photophobia, whereas silencing of DN1s&Pdf-LaNs has no effect. Boxplots indicate median (middle line), 25th and 75th percentile (box), bars represent maximum and minimum. One-way ANOVA, ns: not significant, ***p < 0.001. n = 15 trials for each group. b DN2s but not DN1s receive direct synaptic input from the 5th-LaN as revealed by PER staining in ZT0. Presynaptic GFP (cyan), postsynaptic mtdTomato-HA (magenta) and PER (green). Scale bars, 10 μm. Source data are provided as a Source Data file.
