Table. 2 Top 20 DNMT3A-CHIP-associated CpGs
CpG | CHR | Position | Genea | Discovery in CHS | Replication in ARIC | Combined meta-analysis | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
β (SE) | P | β (SE) | P | β (SE) | P | Directionb | I2 | Het P | ||||
cg04800503 | 17 | 46648533 | HOXB3 | −0.066 (0.0063) | 9.9E−26 | −0.051 (0.0026) | 1.9E−83 | −0.053 (0.0024) | 3.1E−106 | ---- | 48.1 | 0.1227 |
cg23014425 | 17 | 46648525 | HOXB3 | −0.036 (0.0038) | 2.5E−21 | −0.024 (0.0013) | 9.7E−78 | −0.025 (0.0012) | 2.4E−95 | ---- | 80.5 | 0.0015 |
cg25113462 | 2 | 239299293 | TRAF3IP1 | −0.036 (0.0038) | 1.6E−21 | −0.056 (0.0033) | 1.8E−66 | −0.048 (0.0025) | 9.5E−83 | ---- | 82.3 | 0.0007 |
cg07727170 | 15 | 70458214 | −0.019 (0.0024) | 2.2E−15 | −0.030 (0.0018) | 2.9E−61 | −0.026 (0.0014) | 4.4E−72 | ---- | 77.5 | 0.0039 | |
cg23551720 | 17 | 46633726 | HOXB3 | −0.033 (0.0040) | 1.8E−16 | −0.050 (0.0035) | 6.2E−47 | −0.043 (0.0026) | 2.2E−59 | ---- | 74.2 | 0.0088 |
cg03785076 | 2 | 241936915 | SNED1 | −0.067 (0.0067) | 1.3E−23 | −0.060 (0.0048) | 1.7E−35 | −0.062 (0.0039) | 3.1E−57 | ---- | 39.7 | 0.1737 |
cg16937168 | 2 | 241936844 | SNED1 | −0.067 (0.0068) | 2.2E−22 | −0.072 (0.0058) | 2.7E−35 | −0.070 (0.0044) | 7.0E−56 | ---- | 62.9 | 0.0442 |
cg06186155 | 17 | 46648582 | HOXB3 | −0.028 (0.0038) | 6.0E−13 | −0.032 (0.0024) | 5.1E-42 | −0.031 (0.0020) | 4.0E−53 | ---- | 0 | 0.6848 |
cg24400630 | 1 | 89728035 | GBP5 | −0.044 (0.0069) | 1.1E−10 | −0.049 (0.0035) | 1.2E−42 | −0.048 (0.0032) | 1.2E−51 | ---- | 50.6 | 0.1079 |
cg23146197 | 12 | 66271002 | HMGA2 | −0.043 (0.0053) | 6.9E−16 | −0.052 (0.0042) | 4.5E−36 | −0.049 (0.0033) | 6.7E−50 | ---- | 10.6 | 0.3397 |
cg09749364 | 15 | 40384779 | BMF | −0.039 (0.0052) | 9.4E−14 | −0.056 (0.0044) | 7.4E−38 | −0.049 (0.0033) | 1.7E−48 | ---- | 67.2 | 0.0274 |
cg02836478 | 17 | 46652501 | HOXB3 | −0.033 (0.0052) | 2.1E−10 | −0.058 (0.0043) | 1.9E−41 | −0.048 (0.0033) | 3.0E−47 | ---- | 80.7 | 0.0014 |
cg22925751 | 12 | 93509137 | −0.037 (0.0047) | 3.4E−15 | −0.054 (0.0043) | 8.7E−35 | −0.046 (0.0032) | 5.8E−47 | ---- | 68.2 | 0.0241 | |
cg17839959 | 2 | 178421033 | −0.021 (0.0028) | 2.6E−14 | −0.023 (0.0019) | 1.8E−32 | −0.022 (0.0016) | 4.1E−45 | ---- | 0 | 0.9771 | |
cg01525376 | 1 | 32716212 | LCK | −0.031 (0.0041) | 5.9E−14 | −0.033 (0.0028) | 1.3E−32 | −0.032 (0.0023) | 7.0E−45 | ---- | 20.5 | 0.2869 |
cg22506548 | 1 | 2996949 | PRDM16 | −0.065 (0.0107) | 1.1E−09 | −0.043 (0.0034) | 4.6E−37 | −0.045 (0.0032) | 2.8E−44 | ---- | 71.2 | 0.0155 |
cg25911968 | 2 | 69085916 | −0.026 (0.0037) | 2.1E−12 | −0.033 (0.0027) | 7.3E−33 | −0.030 (0.0022) | 3.5E−43 | ---- | 0 | 0.4199 | |
cg24771152 | 6 | 31760608 | VARS | −0.046 (0.0061) | 2.9E−14 | −0.028 (0.0024) | 1.2E−31 | −0.031 (0.0022) | 1.3E−42 | ---- | 79.8 | 0.0019 |
cg22946615 | 10 | 30257569 | −0.036 (0.0064) | 2.0E−08 | −0.042 (0.0033) | 9.7E−36 | −0.040 (0.0030) | 1.8E−42 | ---- | 58.2 | 0.0664 | |
cg13545717 | 9 | 126585875 | DENND1A | −0.043 (0.0046) | 5.8E−21 | −0.045 (0.0045) | 9.6E−23 | −0.044 (0.0032) | 4.9E−42 | ---- | 0 | 0.4182 |