Table. 2 Top 20 DNMT3A-CHIP-associated CpGs

From: Clonal hematopoiesis of indeterminate potential, DNA methylation, and risk for coronary artery disease

CpG

CHR

Position

Genea

Discovery in CHS

Replication in ARIC

Combined meta-analysis

β (SE)

P

β (SE)

P

β (SE)

P

Directionb

I2

Het P

cg04800503

17

46648533

HOXB3

−0.066 (0.0063)

9.9E−26

−0.051 (0.0026)

1.9E−83

−0.053 (0.0024)

3.1E−106

----

48.1

0.1227

cg23014425

17

46648525

HOXB3

−0.036 (0.0038)

2.5E−21

−0.024 (0.0013)

9.7E−78

−0.025 (0.0012)

2.4E−95

----

80.5

0.0015

cg25113462

2

239299293

TRAF3IP1

−0.036 (0.0038)

1.6E−21

−0.056 (0.0033)

1.8E−66

−0.048 (0.0025)

9.5E−83

----

82.3

0.0007

cg07727170

15

70458214

 

−0.019 (0.0024)

2.2E−15

−0.030 (0.0018)

2.9E−61

−0.026 (0.0014)

4.4E−72

----

77.5

0.0039

cg23551720

17

46633726

HOXB3

−0.033 (0.0040)

1.8E−16

−0.050 (0.0035)

6.2E−47

−0.043 (0.0026)

2.2E−59

----

74.2

0.0088

cg03785076

2

241936915

SNED1

−0.067 (0.0067)

1.3E−23

−0.060 (0.0048)

1.7E−35

−0.062 (0.0039)

3.1E−57

----

39.7

0.1737

cg16937168

2

241936844

SNED1

−0.067 (0.0068)

2.2E−22

−0.072 (0.0058)

2.7E−35

−0.070 (0.0044)

7.0E−56

----

62.9

0.0442

cg06186155

17

46648582

HOXB3

−0.028 (0.0038)

6.0E−13

−0.032 (0.0024)

5.1E-42

−0.031 (0.0020)

4.0E−53

----

0

0.6848

cg24400630

1

89728035

GBP5

−0.044 (0.0069)

1.1E−10

−0.049 (0.0035)

1.2E−42

−0.048 (0.0032)

1.2E−51

----

50.6

0.1079

cg23146197

12

66271002

HMGA2

−0.043 (0.0053)

6.9E−16

−0.052 (0.0042)

4.5E−36

−0.049 (0.0033)

6.7E−50

----

10.6

0.3397

cg09749364

15

40384779

BMF

−0.039 (0.0052)

9.4E−14

−0.056 (0.0044)

7.4E−38

−0.049 (0.0033)

1.7E−48

----

67.2

0.0274

cg02836478

17

46652501

HOXB3

−0.033 (0.0052)

2.1E−10

−0.058 (0.0043)

1.9E−41

−0.048 (0.0033)

3.0E−47

----

80.7

0.0014

cg22925751

12

93509137

 

−0.037 (0.0047)

3.4E−15

−0.054 (0.0043)

8.7E−35

−0.046 (0.0032)

5.8E−47

----

68.2

0.0241

cg17839959

2

178421033

 

−0.021 (0.0028)

2.6E−14

−0.023 (0.0019)

1.8E−32

−0.022 (0.0016)

4.1E−45

----

0

0.9771

cg01525376

1

32716212

LCK

−0.031 (0.0041)

5.9E−14

−0.033 (0.0028)

1.3E−32

−0.032 (0.0023)

7.0E−45

----

20.5

0.2869

cg22506548

1

2996949

PRDM16

−0.065 (0.0107)

1.1E−09

−0.043 (0.0034)

4.6E−37

−0.045 (0.0032)

2.8E−44

----

71.2

0.0155

cg25911968

2

69085916

 

−0.026 (0.0037)

2.1E−12

−0.033 (0.0027)

7.3E−33

−0.030 (0.0022)

3.5E−43

----

0

0.4199

cg24771152

6

31760608

VARS

−0.046 (0.0061)

2.9E−14

−0.028 (0.0024)

1.2E−31

−0.031 (0.0022)

1.3E−42

----

79.8

0.0019

cg22946615

10

30257569

 

−0.036 (0.0064)

2.0E−08

−0.042 (0.0033)

9.7E−36

−0.040 (0.0030)

1.8E−42

----

58.2

0.0664

cg13545717

9

126585875

DENND1A

−0.043 (0.0046)

5.8E−21

−0.045 (0.0045)

9.6E−23

−0.044 (0.0032)

4.9E−42

----

0

0.4182

  1. aGene annotations reflect those provided in the Illumina manifest file; probes not annotated to a specific gene were left blank.
  2. bDirection: + and – indicate positive or negative associations in the CHS AA, CHS EA, ARIC AA, and ARIC EA EWAS, respectively.
  3. I2 (heterogeneity statistic) and Het P (heterogeneity P-value) from Cochran's Q test.