Table 3 Top 20 TET2-CHIP-associated CpGs
CpG | CHR | Position | Genea | Discovery in CHS | Replication in ARIC | Combined Meta-analysis | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
β (SE) | P | β (SE) | P | β (SE) | P | Directionb | I2 | Het P | ||||
cg13742400 | 2 | 225639708 | DOCK10 | 0.096 (0.0083) | 2.3E−31 | 0.063 (0.0086) | 3.4E−13 | 0.080 (0.0060) | 3.4E−41 | + + + + | 79.9 | 0.0019 |
cg17607231 | 2 | 231090329 | SP140 | 0.123 (0.0124) | 2.5E−23 | 0.100 (0.0149) | 1.8E−11 | 0.114 (0.0095) | 6.6E−33 | + + + + | 0 | 0.5287 |
cg19695507 | 10 | 13526193 | BEND7 | 0.107 (0.0110) | 2.3E−22 | 0.069 (0.0097) | 1.4E−12 | 0.086 (0.0073) | 6.4E−32 | + + + + | 74 | 0.0091 |
cg26686361 | 16 | 85964073 | 0.119 (0.0123) | 2.6E−22 | 0.095 (0.0142) | 2.3E−11 | 0.109 (0.0093) | 9.6E−32 | + + + + | 10 | 0.3431 | |
cg12976883 | 2 | 231090376 | SP140 | 0.072 (0.0074) | 1.7E−22 | 0.056 (0.0093) | 1.9E−09 | 0.066 (0.0058) | 5.2E−30 | + + + - | 44.8 | 0.1427 |
cg13311440 | 1 | 160681404 | CD48 | 0.072 (0.0077) | 3.4E−21 | 0.058 (0.0093) | 5.6E−10 | 0.066 (0.0059) | 2.7E−29 | + + + + | 13.4 | 0.3253 |
cg10441424 | 5 | 1316636 | 0.035 (0.0033) | 2.3E−26 | 0.015 (0.0033) | 7.1E−06 | 0.025 (0.0024) | 1.1E−26 | + + + + | 84.1 | 0.0003 | |
cg11887996 | 12 | 120559003 | 0.061 (0.0060) | 2.9E−24 | 0.032 (0.0071) | 7.6E−06 | 0.049 (0.0046) | 1.7E−26 | + + + − | 75 | 0.0073 | |
cg18098839 | 3 | 167742700 | GOLIM4 | 0.058 (0.0067) | 5.1E−18 | 0.044 (0.0070) | 3.0E−10 | 0.051 (0.0048) | 2.9E−26 | + + + − | 42.6 | 0.1561 |
cg14064762 | 9 | 123688745 | TRAF1 | 0.068 (0.0080) | 2.0E−17 | 0.063 (0.0100) | 3.6E−10 | 0.066 (0.0062) | 5.0E−26 | + + + + | 0 | 0.8771 |
cg00476771 | 5 | 64398066 | 0.094 (0.0101) | 1.5E−20 | 0.073 (0.0143) | 2.9E−07 | 0.087 (0.0083) | 5.0E−26 | + + + + | 0 | 0.6430 | |
cg18642369 | 13 | 99651231 | DOCK9 | 0.111 (0.0130) | 9.4E−18 | 0.104 (0.0176) | 2.7E−09 | 0.109 (0.0104) | 1.7E−25 | + + + + | 0 | 0.4166 |
cg05165553 | 18 | 77171010 | NFATC1 | 0.076 (0.0080) | 2.1E−21 | 0.042 (0.0088) | 1.5E−06 | 0.061 (0.0059) | 1.0E−24 | + + + − | 82.5 | 0.0007 |
cg27133780 | 3 | 32474793 | CMTM7 | 0.084 (0.0099) | 2.7E−17 | 0.073 (0.0126) | 5.3E−09 | 0.080 (0.0078) | 1.1E−24 | + + + − | 33.6 | 0.2107 |
cg20556803 | 7 | 2114593 | MAD1L1 | 0.084 (0.0087) | 2.6E−22 | 0.048 (0.0118) | 5.1E−05 | 0.071 (0.0070) | 1.5E−24 | + + + + | 69.5 | 0.0201 |
cg08698943 | 10 | 3509758 | 0.090 (0.0108) | 1.5E−16 | 0.079 (0.0137) | 9.3E−09 | 0.086 (0.0085) | 1.0E−23 | + + + + | 0 | 0.4917 | |
cg08220966 | 10 | 88717364 | MMRN2; SNCG | 0.063 (0.0067) | 7.1E−21 | 0.036 (0.0089) | 5.0E−05 | 0.053 (0.0053) | 3.1E−23 | + + + − | 72.9 | 0.0114 |
cg09667606 | 6 | 158507930 | SYNJ2 | 0.080 (0.0087) | 3.1E−20 | 0.044 (0.0095) | 3.8E−06 | 0.064 (0.0064) | 3.3E−23 | + + + + | 67.6 | 0.0259 |
cg13273540 | 3 | 176850227 | TBL1XR1 | 0.081 (0.0096) | 4.4E−17 | 0.056 (0.0101) | 3.6E−08 | 0.069 (0.0070) | 5.1E−23 | + + + + | 60.2 | 0.0564 |
cg18739367 | 8 | 38330740 | 0.060 (0.0070) | 5.6E−18 | 0.043 (0.0084) | 4.8E−07 | 0.053 (0.0054) | 5.7E−23 | + + + + | 26.6 | 0.2522 | |
