Fig. 2: TERT promoter duplication confers GABP dependency by contributing a de novo ETS factor binding site. | Nature Communications

Fig. 2: TERT promoter duplication confers GABP dependency by contributing a de novo ETS factor binding site.

From: Conserved features of TERT promoter duplications reveal an activation mechanism that mimics hotspot mutations in cancer

Fig. 2

a TERTp luciferase reporter assays for wildtype (WT), two hotspot mutants and 20 unique duplications 72 h after siRNA knockdown of control or GABPA in UMUC3 cells. b TERTp luciferase reporter assays for wildtype, two hotspot mutants and 20 duplication constructs representing 17 unique sequences 72 h after siRNA knockdown of control or GABPA in LN229 cells. Values are mean and SD. N = 2 independent experiments. TERTp TERT promoter, NT Non-targeting. Source data are provided as a Source Data file.

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