Table 1 Tumor samples with an ETS binding site duplication in the TERT promoter

From: Conserved features of TERT promoter duplications reveal an activation mechanism that mimics hotspot mutations in cancer

Duplicated Region¹	Duplicated Sequence	Insert Size (bp)	Insert Position⁵		Other Acquired ETS Variants	Age	Race	Sex	Cancer Type	Tumor Type	Dataset
Duplicated Region¹	Duplicated Sequence	Insert Size (bp)	Start	End	Other Acquired ETS Variants	Age	Race	Sex	Cancer Type	Tumor Type	Dataset
c.-100_-79	GGGCGGGGCCGCGGAAAGGAAG	22	1295182	1295183	NA	NA	NA	NA	Glioblastoma Multiforme	NA	Pierini et al.
c.-100_-79²	GGGCGGGGCCGCGGAAAGGAAG	22	1295182	1295183	None	54	NA	Male	Glioblastoma Multiforme	NA	UCSF500
c.-100_-79	GGGCGGGGCCGCGGAAAGGAAG	22	1295182	1295183	G228A	29	NA	Female	Squamous Cell Carcinoma	Metastasis	UCSF500
c.-100_-79	GGGCGGGGCCGCGGAAAGGAAG	22	1295182	1295183	None	68	White	Male	Duodenal Adenocarcinoma	Metastasis	GENIE
c.-100_-79³	GGGCGGGGCCGCGGAAAGGAAG	22	1295182	1295183	None	48	NA	Male	Glioblastoma Multiforme	Primary	UCSF500
c.-100_-79³	GGGCGGGGCCGCGGAAAGGAAG	22	1295182	1295183	None	48	NA	Male	Glioblastoma Multiforme	Primary	UCSF500
c.-100_-79³	GGGCGGGGCCGCGGAAAGGAAG	22	1295182	1295183	None	48	NA	Male	Glioblastoma Multiforme	Recurrent	UCSF500
c.‐104_‐83	GGGGCCGCGGAAAGGAAGGGGA	22	1295186	1295187	None	42	Asian	Male	Oral Cavity Squamous Cell Carcinoma	Metastasis	GENIE
c.‐104_‐83	GGGGCCGCGGAAAGGAAGGGGA	22	1295186	1295187	None	50	White	Male	Bladder Urothelial Carcinoma	Primary	GENIE
c.‐104_‐83	GGGGCCGCGGAAAGGAAGGGGA	22	1295186	1295187	None	68	Black	Male	Hepatocellular Carcinoma	Primary	GENIE
c.‐104_‐83	GGGGCCGCGGAAAGGAAGGGGA	22	1295186	1295187	NA	NA	NA	NA	Papillary Thyroid Cancer	NA	Panebianco et al.
c.-110_-89	GCGGAAAGGAAGGGGAGGGGCT	22	1295192	1295193	None	48	Asian	Female	Malignant Phyllodes Tumor of the Breast	Primary	GENIE
c.-110_-89	GCGGAAAGGAAGGGGAGGGGCT	22	1295192	1295193	None	64	White	Male	Glioblastoma Multiforme	Primary	GENIE
c.-110_-89	GCGGAAAGGAAGGGGAGGGGCT	22	1295192	1295193	None	65	NA	Male	Glioblastoma Multiforme	Primary	GENIE
c.-110_-89⁴	GCGGAAAGGAAGGGGAGGGGCTA	23	1295192	1295193	None	69	White	Female	Papillary Thyroid Cancer	Metastasis	GENIE
c.-110_-89⁴	GCGGAAAGGAAGGGGAGGGGCTA	23	1295192	1295193	None	72	White	Female	Poorly Differentiated Thyroid Cancer	Metastasis	GENIE
c.-110_-89	GCGGAAAGGAAGGGGAGGGGCT	22	1295192	1295193	NA	NA	NA	NA	Glioblastoma Multiforme	NA	Pierini et al.
c.-116_-96	GGAAGGGGAGGGGCTGGGAGG	21	1295199	1295200	None	64	White	Male	Hepatocellular Carcinoma	Primary	GENIE
c.-120_-96	GGAAGGGGAGGGGCTGGGAGGGCCC	25	1295199	1295200	None	80	NA	Female	Poorly Differentiated Thyroid Cancer	NA	UCSF500
c.-120_-96	GGAAGGGGAGGGGCTGGGAGGGCCC	25	1295199	1295200	None	68	White	Male	Hepatocellular Carcinoma	Primary	GENIE
c.-125_-106	*GGGGCT*GGGCTGGGAGGGCCCGGAA	25	1295228	1295229	G228A	69	White	Male	Bladder Urothelial Carcinoma	Metastasis	GENIE

¹Duplicated region of the TERTp relative to TERT translation start site (ATG);
²SF5681.
³Primary and recurrent tumors for the same patient, SF12747 and SF13241;
⁴Two metastatic tumors for the same patient;
⁵Human reference genome hg19, chromosome 5; De novo native ETS 195 motif is in bold while de novo ETS 200 motif is underlined, and de novo ETS motif is in italic. Bold and italic nucleotides in the duplication sequence indicate a mismatch when compared to the duplication template sequence. NA Not available.

Back to article page

Table 1 Tumor samples with an ETS binding site duplication in the TERT promoter

Search

Quick links