Fig. 4: Marmoset WM-OPC form a transcriptionally disparate population that diverges from previously reported OPC in other species.
From: Transcriptomic architecture of nuclei in the marmoset CNS
a Left, UMAP plot of OPC colored by Level 2 subclustering. Right, relative abundance of OPC subclusters in coarse tissue category; n = 42 independent samples; the median is annotated (black diamond shape) and listed. The lower and upper hinges of the box plot correspond to the 25th and 75th percentiles, whiskers extend from the hinges to maxima or minima at most 1.5 times inter-quartile range. b Heatmap showing the Pearson’s correlation coefficient r) between 6 oligodendrocyte-lineage cell clusters (OPC1–5 and all oligodendrocytes, see Fig. 5) from marmoset and multiple subclusters of oligodendrocyte-lineage cells in zebrafish (dr), mouse (mm), and human (hs). d.p.f. days post fertilization, P postnatal day, GW gestational weeks. c Scatter plot showing the ratio of r2 between OPC2 and OPC1 (left) and OPC3 and OPC1 (right). OPC1 and OPC2 are similar to one another and to OPC found in other species. WM-OPC (OPC3) is a distinct subcluster, in general showing lower similarity with previously defined clusters compared to GM-OPC (OPC1), though it is relatively more similar to human than mouse or zebrafish OPC.
