Fig. 9: GM- and WM-glia diverge in disease contribution.
From: Transcriptomic architecture of nuclei in the marmoset CNS
a Bar and UpSet plots showing the overlap of genes associated with various neurological disorders as defined in the Ingenuity Pathway Analysis (IPA) database. The number of genes is listed next to the name of the disorder (bottom panel, y axis label). The number of intersecting genes between indicated disorders (solid black dot and line), but not shared by any other disorders (empty gray dot), is labeled and shown on the bar graph (top panel). b Bar graph showing standard deviation (top) and fold-change (bottom) of the enrichment probability for neurological disorder-associated genes calculated by expression-weighted cell-type enrichment (EWCE) analysis, after bootstrapping. Bar color represents the Level 1 cell class of origin. Genes annotated in the IPA database associated with an organic mental disorder, CNS tumor, multiple sclerosis, and List.21 (27 genes, shared by encephalitis and CNS tumor but not by other neurological disorders) were analyzed and plotted. The significance of cell-type enrichment is denoted after Benjamini-Hochberg correction, *q < 0.05 and °q < 0.1.
