Fig. 8: RAS co-opts mTORC1 and the amino acid sensing machinery to drive oncogenic growth in MM. | Nature Communications

Fig. 8: RAS co-opts mTORC1 and the amino acid sensing machinery to drive oncogenic growth in MM.

From: Oncogenic RAS commandeers amino acid sensing machinery to aberrantly activate mTORC1 in multiple myeloma

Fig. 8

Model of oncogenic RAS signaling in MM: (1) Oncogenic isoforms of RAS (KRAS or NRAS) promote localization of SLC3A2 and MTOR to endolysosomes with oncogenic RAS. (2) RAS associates with PI3-K and TSC2 to promote full activation of mTORC1 signaling. (3) RAS stimulates classical MAPK signaling.

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