Fig. 6: Functional impact of PML NB-facilitated sumoylation. | Nature Communications

Fig. 6: Functional impact of PML NB-facilitated sumoylation.

From: Exploration of nuclear body-enhanced sumoylation reveals that PML represses 2-cell features of embryonic stem cells

Fig. 6

PML NBs enhance the sumoylation of partner proteins (in pink). Through control of their sumoylation, PML coordinates the activity of KAP1 and DPPA2, orchestrating the inhibition of 2CL features. These key regulators of mESC fate silence ERVs and 2CL genes. Depending on the cell environment, PML NBs may also drive an adaptative stress response.

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