Table 1 Model-based simulation scenarios
From: The design and evaluation of hybrid controlled trials that leverage external data and randomization
Scenarios | Distribution of pre-treatment variables in the EC population | Effect of pre-treatment variables on the outcome in the EC (and HT) population | Response rates for the EC, IC, and EXPT | ||||||
---|---|---|---|---|---|---|---|---|---|
\({p}_{1}\) | \({p}_{2}\) | \({p}_{3}\) | \({\theta }_{S,1}\) | \({\theta }_{S,2}\) | \({\theta }_{S,3}\) | EC | IC and EXPT (TE = 0) | EXPT (TE > 0) | |
1 | 0.2 | 0.8 | 0.5 | 0.5 | −0.5 | 0.0 | 0.43 | 0.50 | 0.68 |
2 | 0.2 | 0.8 | 0.1 | 0.5 | −0.5 | 1.5 | 0.46 | 0.66 | 0.79 |
3 | 0.2 | 0.8 | 0.9 | 0.5 | −0.5 | 1.5 | 0.73 | 0.66 | 0.79 |
4 | 0.2 | 0.8 | 0.1 | 0.5 | −1.5(1.5) | 1.5 | 0.30 | 0.66 | 0.79 |
5 | 0.2 | 0.8 | 0.9 | 0.5 | −1.5(1.5) | 1.5 | 0.55 | 0.66 | 0.79 |