Fig. 1: An overview of the CONTENT approach.
From: Multi-context genetic modeling of transcriptional regulation resolves novel disease loci
CONTENT first decomposes the observed expression for each individual into context-specific and context-shared components following16. Then, CONTENT fits predictors for the context-shared component of expression as well as each context-specific component of expression (e.g., liver). Finally, for a given context, CONTENT combines the genetically predicted components into the full model using a simple regression. Icons were created with BioRender.com.
