Table 1 Overview of lead SNPs with significant associations at 29 independent loci in UL GWAS meta-analysis

From: Author Correction: Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis

Locus

Lead SNP

RA

OA

RAFEUR

PMeta

OR (95% CI)

Gene(s) of interesta

1p36.12b,c

rs7412010

C

G

0.15

2.4 × 10−29

1.13 (1.11–1.16)

WNT4, CDC42

2p23.2

rs55819434

A

G

0.91

5.6 × 10−09

0.92 (0.90–0.95)

BABAM2

2p25.1b,c

rs35417544

T

C

0.69

2.3 × 10−19

1.09 (1.07–1.10)

GREB1

3q26.2c

rs35446936

A

G

0.24

1.0 × 10−08

0.95 (0.93–0.96)

TERC

4q12c

rs62323682

T

C

0.94

4.9 × 10−18

0.87 (0.84–0.90)

LNX1, PDGFRA

4q13.3c

rs12640488

A

G

0.52

4.0 × 10−14

0.94 (0.92–0.96)

SULT1B1

4q22.3

rs4699299

T

C

0.69

4.7 × 10−08

0.95 (0.94–0.97)

PDLIM5

5p15.33c

rs72709458

T

C

0.23

4.7 × 10−21

1.10 (1.08–1.13)

TERT

5q35.2c

rs2456181

C

G

0.49

1.1 × 10−11

0.94 (0.93–0.96)

ZNF346, UIMC1

6p21.31

rs116251328

A

T

0.02

3.0 × 10−08

1.15 (1.09–1.21)

GRM4, HMGA1

6q25.2b,c

rs58415480

C

G

0.84

1.9 × 10−54

0.84 (0.82–0.86)

SYNE1, ESR1

7q31.2

rs2270206

A

C

0.16

4.6 × 10−08

1.06 (1.04–1.09)

WNT2

9p24.3c

rs10976689

A

G

0.60

2.4 × 10−13

0.94 (0.93–0.96)

ANKRD15

10q24.3c

rs9419958

T

C

0.13

1.1 × 10−16

1.10 (1.08–1.13)

OBFC1, SLK

10p11.22

rs10508765

A

G

0.80

1.5 × 10−10

1.07 (1.05–1.09)

ZEB1, ARHGAP12

11p15.5c

rs547025

T

C

0.92

1.5 × 10−14

1.13 (1.09–1.16)

RIC8A, BET1L

11p14.1b

rs11031006

A

G

0.14

5.7 × 10−15

0.91 (0.89–0.93)

FSHB

11p13c

rs61889186

C

G

0.86

1.4 × 10−25

0.89 (0.87–0.91)

WT1

11p13c

rs2785202

C

G

0.55

6.9 × 10−14

1.06 (1.05–1.08)

PDHX, CD44

11q22.3c

rs149934734

T

C

0.03

1.1 × 10−27

1.33 (1.26–1.40)

C11orf65, KDELC2

12q13.11c

rs2131371

A

C

0.28

1.6 × 10−18

0.93 (0.91–0.94)

SLC38A2

12q15

rs11178393

T

C

0.89

3.3 × 10−08

1.08 (1.05–1.10)

PTPRR

12q24.31

rs28583837

A

G

0.22

2.3 × 10−08

0.94 (0.92–0.96)

PITPNM2

13q14.11c

rs117245733

A

G

0.02

5.7 × 10−14

1.31 (1.21–1.39)

FOXO1

17p13.1c

rs78378222

T

G

0.99

7.1 × 10−31

0.65 (0.60–0.70)

SHBG, TP53

20p12.3c

rs16991615

A

G

0.07

8.8 × 10−10

1.11 (1.07–1.14)

MCM8, TRMT6

22q13.1c

rs4821939

A

T

0.20

7.8 × 10−16

1.08 (1.06–1.10)

TNRC6B

Xp26.2c

rs12392108

A

T

0.31

5.9 × 10−46

1.13 (1.11–1.15)

RAP2C

Xq13.1c

rs4360450

A

G

0.37

2.1 × 10−18

1.08 (1.06–1.10)

MED12

  1. SNP single-nucleotide polymorphism, RA risk allele, OA other allele, RAFEUR average risk allele frequency in European samples, OR odds ratio
  2. a≤300 kb distant from association signal
  3. bLoci previously associated with endometriosis
  4. cLoci previously associated with UL
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