Table 2 Treatment-related adverse events (TRAEs)
Any Grade | Grade 3 | Grade 4 | ||||
|---|---|---|---|---|---|---|
Event | N | % | N | % | N | % |
Any TRAEs | 42 | 97.7 | 33 | 76.7 | 2 | 4.7 |
Hematologic | ||||||
Neutrophil count decreased | 20 | 46.5 | 17 | 39.5 | 1 | 2.3 |
Anemia | 14 | 32.6 | 7 | 16.3 | 0 | 0 |
Platelet count decreased | 7 | 16.3 | 3 | 7 | 0 | 0 |
Febrile neutropenia | 5 | 11.6 | 4 | 9.3 | 0 | 0 |
Non-hematologic | ||||||
Anorexia | 17 | 39.5 | 2 | 4.7 | 0 | 0 |
Nausea | 14 | 32.6 | 0 | 0 | 0 | 0 |
Creatinine increased | 13 | 30.2 | 2 | 4.7 | 0 | 0 |
Diarrhea | 13 | 30.2 | 1 | 2.3 | 0 | 0 |
Hand-foot syndrome | 10 | 23.3 | 0 | 0 | 0 | 0 |
Oral mucositis | 10 | 23.3 | 1 | 2.3 | 0 | 0 |
General weakness | 8 | 18.6 | 1 | 2.3 | 0 | 0 |
Peripheral neuropathy | 8 | 18.6 | 0 | 0 | 0 | 0 |
Abdominal pain | 6 | 14 | 0 | 0 | 0 | 0 |
Fever | 6 | 14 | 0 | 0 | 0 | 0 |
Hypoalbuminemia | 2 | 4.7 | 1 | 2.3 | 0 | 0 |
Hyperkalemia | 2 | 4.7 | 2 | 4.7 | 0 | 0 |
Tinnitus | 2 | 4.7 | 0 | 0 | 0 | 0 |
Thromboembolic event | 2 | 4.7 | 0 | 0 | 1 | 2.3 |
Immune-related | ||||||
Hypothyroidism | 5 | 11.6 | 0 | 0 | 0 | 0 |
Allergic reaction | 4 | 9.3 | 1 | 2.3 | 0 | 0 |
Pruritus | 4 | 9.3 | 0 | 0 | 0 | 0 |
Colitis | 3 | 7 | 3 | 7 | 0 | 0 |
Adrenal insufficiency | 2 | 4.7 | 0 | 0 | 0 | 0 |
Hyperglycemia | 2 | 4.7 | 0 | 0 | 0 | 0 |
Skin rash | 2 | 4.7 | 0 | 0 | 0 | 0 |
