Fig. 4: Structural comparison of METTL4 and METTL3/METTL14. | Nature Communications

Fig. 4: Structural comparison of METTL4 and METTL3/METTL14.

From: Structural insights into molecular mechanism for N6-adenosine methylation by MT-A70 family methyltransferase METTL4

Fig. 4

a Superposition of the METTL4 with METTL3-METTL14 heterodimer. b Close-up view of the catalytic pocket formed by the four loops in the MTase domains of METTL4 and METTL3, and the key residues were shown as sticks. c Structural superposition of METTL4 and METTL3 shows the Gate Loop2 makes clashes with Am. d The NTD makes interaction with Gate Loop2 of MTase domain. e Modeled catalytic center of METTL4 by replacing SAH with SAM. f Structural superposition of the catalytic center of METTL4 and METTL3.

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