Fig. 5: Proposed catalytic mechanism of METTL4. | Nature Communications

Fig. 5: Proposed catalytic mechanism of METTL4.

From: Structural insights into molecular mechanism for N6-adenosine methylation by MT-A70 family methyltransferase METTL4

Fig. 5

Diagrammatic presentation of the catalytic mechanism of METTL4. In the initial step (1) the backbone phosphate of Am may be bound by H321 in interface loop; then, Y247 in the Gate Loop1 interacts with N6 of Am (2), followed by hydrogen binding from D233 and P234 and methyl group transferred from SAM to N6 of Am (3). Finally, N6-methylated Am is released from the pocket due to the steric clash (4).

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