Fig. 1: Clinical timeline. | Nature Communications

Fig. 1: Clinical timeline.

From: Bacteriophage-antibiotic combination therapy against extensively drug-resistant Pseudomonas aeruginosa infection to allow liver transplantation in a toddler

Fig. 1

Timeline of the most relevant surgical procedures (light green), microbiological results (light blue), antibiotic therapies (dark gray), pre- and post-liver transplantation protocols (blue-green), and phage therapy (magenta). The child developed several early-onset post-operative complications, including liver rejection, anaphylactic shock on rituximab, biliary digestive anastomosis perforation followed by an Escherichia coli and Enterococcus faecium sepsis, and cytomegalovirus (CMV) infection. At day 53 post-LDLT, he entered a severe septicemia due to XDR Pseudomonas aeruginosa. ABOc ABO compatible, ABOi ABO incompatible, BFC1 “bacteriofaagcocktail 1”, CMV cytomegalovirus, DDLT deceased-donor liver transplantation, EC ethics committee, IA intra-abdominal, IL intralesional, IV intravenous, LDLT living-donor liver transplantation, pfu plaque forming unit, PICU pediatric intensive care unit, VIM Verona integron-encoded metallo-β-lactamase, XDR extensively drug-resistant.

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