Fig. 2: Circular chromosomic view (CCV) of the bacterial genomes of seven Pseudomonas aeruginosa isolates retrieved just before (Pa1BS) and during (Pa2BR–Pa7BS) phage therapy. | Nature Communications

Fig. 2: Circular chromosomic view (CCV) of the bacterial genomes of seven Pseudomonas aeruginosa isolates retrieved just before (Pa1BS) and during (Pa2BR–Pa7BS) phage therapy.

From: Bacteriophage-antibiotic combination therapy against extensively drug-resistant Pseudomonas aeruginosa infection to allow liver transplantation in a toddler

Fig. 2

The CCV algorithm chose strain Pa3LS as reference (inner circle). From the inner to outer rings of the CCV, two green rings display the genomic variations in phage PNM-susceptible isolates Pa1BS and Pa7BS, and four outer red rings display the genomic variations in phage PNM-resistant isolates Pa2BR, Pa4BR, Pa5LR, and Pa6LR. The two multi-colored outer rings display the protein annotations (categories) as present in the database of Clusters of Orthologous Groups of proteins (COGs). aa amino acid, bp basepairs, CDS coding sequence, IS insertion sequence, Mb megabases, nt nucleotide, PAGI Pseudomonas aeruginosa genomic island, PTM post-translational modification; SNP single-nucleotide polymorphism.

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