Fig. 1: Tamoxifen kills ER-negative breast cancer cells and animals.
From: Bacterial diet modulates tamoxifen-induced death via host fatty acid metabolism
a, b The growth rate index (a) and fractional viability (b) of ER-positive (T-47D) and ER-negative (MDA-MB-231) breast cancer cells plotted as a function of increasing concentrations of tamoxifen. Data were represented as mean ± SD of four technical replicates. Representative results of one out of three independent experiments. c Bright-field images showing C. elegans supplemented with increasing doses of tamoxifen, fed E. coli, C. aquatica, and B. subtilis. Images were taken at 2x magnification after 48 h exposure to tamoxifen. Scale bars: 1 mm. Representative results of one out of three independent experiments. d Dose-response curves (DRCs) of C. elegans supplemented with increasing doses of tamoxifen, fed E. coli, C. aquatica, and B. subtilis. Data were represented as mean ± SEM of three independent biological replicates. Statistical analysis of DRCs was conducted by performing two-way ANOVA followed by a Dunnett multi-comparison test using the E. coli condition as a control on GraphPad Prism (v9). Adjusted p values < 0.0001 (C. aquatica and B. subtilis). Source data are provided as a Source Data file.
