Fig. 9: BNC1-Merlin-Hippo-YAP signaling -Ferroptosis axis. | Nature Communications

Fig. 9: BNC1-Merlin-Hippo-YAP signaling -Ferroptosis axis.

From: BNC1 deficiency-triggered ferroptosis through the NF2-YAP pathway induces primary ovarian insufficiency

Fig. 9

BNC1 directly regulates Nf2 expression. BNC1 deficiency downregulates NF2 expression, which reduces YAP phosphorylation and promote YAP nuclear accumulation. YAP activation upregulates Tfrc and Acsl4 expression, followed by increased iron uptake and enhanced lipid ROS production, which ultimately leads to oocyte ferroptosis.

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