Fig. 7: IL-23 receptor signaling decreases ferroptosis and inflammation during disseminated candidiasis.
From: IL-23 signaling prevents ferroptosis-driven renal immunopathology during candidiasis
a Renal fungal burden after 3 days of infection. N = 6; combined data of two independent experiments. Two-tailed Mann–Whitney Test. b, c Lipid peroxidation (4HNE) in infected kidneys after 3 days of infection. 4HNE shown in red, tissue stained with DAPI (blue). Scale bar 100 μm. Quantification of mean fluorescence intensity (MFI) per high-power field (HPF). N = 10 immunofluorescence pictures for Il23rWT/WT and N = 9 for Il23rGFP/GFP; combined data of two independent experiments. Two-tailed Mann–Whitney Test. d Serum NGAL and e TREM1 of infected mice after 3 days of infection. N = 6; combined data of two independent experiments. Two-tailed Mann–Whitney Test. f Levels of TNFα, IL-1β, and IL-6 in infected kidneys after 3 days of infection. N = 6; combined data of two independent experiments. Two-tailed Mann–Whitney Test. Results are median ± SEM.
