Fig. 9: IL-23 depletion in Epha2–/– mice increases ferroptosis and worsens disease severity.
From: IL-23 signaling prevents ferroptosis-driven renal immunopathology during candidiasis
a Survival of wild-type mice infected intravenously with 2.5 × 105 SC5314 C. albicans. N = 5; combined data of two independent experiments. Mantel–Cox Log-Rank test. b Renal fungal burden after 3 days of infection. N = 6 for each group; combined data of two independent experiments. Two-tailed Mann–Whitney Test. c, d Lipid peroxidation in infected kidneys after 3 days of infection using 4HNE. 4HNE shown in green, C. albicans (Ca) in red. Tissue is visualized using DAPI. Scale bar 100 μm. Quantification of mean fluorescence intensity (MFI) per high power field (HPF). N = 10 immunofluorescence pictures. Two-tailed Mann–Whitney Test. e Serum NGAL and f TREM1 of infected mice after 3 days of infection. N = 6; combined data of two independent experiments. Two-tailed Mann–Whitney Test. g Levels of TNFα, IL-1β, and IL-6 in infected kidneys after 3 days of infection. N = 6; combined data of two independent experiments. Two-tailed Mann–Whitney Test. Results are median ± SEM.
