Fig. 2: Biological pathways and upstream regulators associated with enrichment of the IL-22 regulated transcriptional program. | Nature Communications

Fig. 2: Biological pathways and upstream regulators associated with enrichment of the IL-22 regulated transcriptional program.

From: Interleukin-22 regulates neutrophil recruitment in ulcerative colitis and is associated with resistance to ustekinumab therapy

Fig. 2

a Pathway enrichment analysis (IPA) of the differentially expressed genes in patients enrolled in UNIFI with high enrichment for the IL-22 transcriptional program (right-tailed Fisher’s exact test), b genes belonging to “Migration of cells” pathway that are upregulated in patients with high enrichment of the IL-22 transcriptional program, as identified using IPA downstream analysis. Genes have been further subdivided into functional categories. Symbols denote type of protein, color denotes regulation and color of line denotes relationship, c regulator effects analysis performed on the top 3 predicted upstream activators by IPA in the patients with high enrichment for the IL22 transcriptional program, d normalized expression intensity (to healthy controls, n = 18) of known IL-22 regulators stratified by the IL-22 transcriptional program enrichment (UNIFI, UC n = 550, Kruskal–Wallis test with Dunn multiple comparisons test, *p < 0.05, **p < 0.01, ***p < 0.001). Source data for a and d are provided as a Source Data file.

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