Fig. 2: In vivo fluorescence imaging with intravenous injected Au-PC, Au-GSH and ICG. | Nature Communications

Fig. 2: In vivo fluorescence imaging with intravenous injected Au-PC, Au-GSH and ICG.

From: Phosphorylcholine-conjugated gold-molecular clusters improve signal for Lymph Node NIR-II fluorescence imaging in preclinical cancer models

Fig. 2

Wide-field NIR-II fluorescence images (excited by an 808 nm laser at a power density of 70 mW/cm2, exposure times 40 ms and 4 ms for Au and ICG, respectively, 1100 nm long pass filter) of intravenously (i.v.) injected a Au-PC conjugate (4x, ~ 1.2 mg), b Au-GSH cluster (4x, ~1.2 mg) and (c) ICG (50 µL, 50 mM) probes at different time points (six to seven weeks old female Balb/c, n = 3). Biodistribution in major organs at 24 h post-injection of d Au-PC and e Au-GSH fluorescent probes. Error bars represent standard deviation (SD) of three repeated experiments. Bar graphs data presented as mean values ± SD. f Microanatomy of histological sections of hematoxylin and eosin (H&E)-stained major organs from healthy mouse and mouse injected with Au-PC conjugate 24 h postinjection (20x objective, scale bar is 100 µm). Source data are provided in Source Data file.

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