Fig. 7: Effects of CD36 on tumor immunity.
From: CD36-mediated metabolic crosstalk between tumor cells and macrophages affects liver metastasis
a, Percentages of indicated cell populations among CD45+ cells in metastatic liver tumors or normal livers of WT and Cd36−/− mice (n = 3). b, Immunohistochemistry staining of F4/80 in the liver sections from the WT and Cd36−/− mice at indicated times along with the quantification (n = 6). Scale bar, 100 μm. c, d, Representative histogram (left) and quantitative results of the MFI of CD206 or CD80 staining in MAMs on day 18 (n  =  3). e, Numbers of indicated cell populations in the metastatic liver tumors of WT and Cd36lysm-cre mice on day 12 (n = 5). f, g, Representative histogram (left) and quantitative results of the MFI of CD206 or CD80 staining in MAMs (n  =  5). h, i, CD8+ T cells were isolated from the metastatic liver tumors of WT and Cd36lysm-cre mice and the production of GzmB (h, n = 6) and IFN-γ (i, n = 6) was assessed. j, M1 or M2-type macrophage numbers in Cd36low (n = 18) and Cd36high (n = 18) expression groups in patients with liver metastasis (GSE68468). k, The correlation of CD36 with M2-type macrophage infiltration in patients with liver metastasis from two GEO datasheets (n = 36, 116 respectively). P value was calculated by Pearson correlation analysis. Values for n represent biologically independent samples. Data are mean ± SEM and P values were determined by unpaired two-tailed Student’s t-test (a–g). Source data are provided as a Source Data file.
