Fig. 2: 1-month-old SNR-derived organoids consist of telencephalic neural progenitors and both excitatory and inhibitory neurons. | Nature Communications

Fig. 2: 1-month-old SNR-derived organoids consist of telencephalic neural progenitors and both excitatory and inhibitory neurons.

From: Modeling human telencephalic development and autism-associated SHANK3 deficiency using organoids generated from single neural rosettes

Fig. 2

a Cartoon depicting collection of single cells from individual organoids for single-cell RNA sequencing (elements were drawn by Coni Hoerndli Science Design). b UMAP visualization of unsupervised cell clustering (n = 4 organoids from H9, and 2242-5 lines). c Heatmap of relative gene expression similarity between different cell clusters. d  UMAP visualization of unsupervised cell clustering from individual organoids. e Percentages of cells from different organoids in different cell clusters. f Dot plot visualization of expression of different cell type-specific markers. g Heatmap visualizations of expression of different cell type-specific markers. NP neural progenitor, IP intermediate neural progenitor, nEN newborn excitatory neuron, nIN newborn inhibitory neuron.

Back to article page