Fig. 2: Optimization of the reaction conditions. | Nature Communications

Fig. 2: Optimization of the reaction conditions.

From: Ni-catalyzed carbamoylation of unactivated alkenes for stereoselective construction of six-membered lactams

Fig. 2

The reaction was performed with carbamoyl chloride 1a (1.0 eq.), iodoheptane 2a (3.0 eq.), Ni(ClO4)2•6H2O (15 mol%), Ligand (18 mol%), Mn (4.0 eq.), LiBr (1.0 eq.), DMA (0.2 M), stirred for 24 h under 30 °C. The yields were reported as corrected GC yield and the er values were determined by chiral HPLC analysis on a chiral stationary phase. a1.0 eq. LiI. bThe reaction was performed in DMA/MeCN (v/v = 4/1), isolated yield on 0.2 mmol scale for 48 h was reported in parentheses.

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