Fig. 1: High-resolution Hi-C identifies human retinal chromatin structures. | Nature Communications

Fig. 1: High-resolution Hi-C identifies human retinal chromatin structures.

From: High-resolution genome topology of human retina uncovers super enhancer-promoter interactions at tissue-specific and multifactorial disease loci

Fig. 1

A Schematic of project workflow. Input data on blue backgrounds were generated in this manuscript; input data on yellow backgrounds were downloaded from public databases. Hi-C contact maps of observed contacts across (B) all chromosomes, (C) the q arm of chromosome 14, and (D) the NRL and VSX2/ESRRB loci. Scale represents the number of raw contacts. Loops at the NRL and VSX2/ESRRB loci are plotted on the top; contact maps are below with TADs plotted as black triangles. E Distribution of chromatin loop sizes within and across A/B compartments (n = 15,441 loops within A compartment, n = 4318 loops within B compartments, n = 2697 loops in A-B compartments). Boxplots represent the median and interquartile range (IQR); whiskers mark 1.5x the IQR; data beyond 1.5x the IQR are plotted as individual points. The three groups differ significantly (one-way ANOVA, F2,22453 = 2232, p < 0.001). Abbreviations: ROSE Rank Ordering of Super-Enhancers, AMD Age-related macular degeneration, GWAS Genome-wide association study.

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