Fig. 5: Use of enantioenriched allyl pyridines as pharmaceutical precursors.
From: Palladium-catalyzed asymmetric allylic 4-pyridinylation via electroreductive substitution reaction
a Reaction at 10 mmol scale. b Synthesis of chiral precursor of tachykinin/serotonin reuptake inhibitor. c Synthesis of chiral precursor of calcium receptor modulator. 9-BBN, 9-borabicyclo[3.3.1]nonane; DMP: Dess-Martin periodinane; DIAD, diisopropyl azodicarboxylate.
