Fig. 1: cfDNA concentration in saliva and serum is positively correlated with the severity of periodontal inflammation, and cfDNA in saliva showed stronger correlation.
From: Nanoparticulate cell-free DNA scavenger for treating inflammatory bone loss in periodontitis
a cfDNA levels in saliva and serum of healthy volunteers (n = 10), gingivitis patients (n = 10) and periodontitis patients (n = 10). Data are means ± SEM; differences were assessed by one-way analysis of variance and Tukey’s multiple comparisons test. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 (Saliva, P = 0.0004 between Healthy and Periodontitis, P = 0.0302 between Gingivitis and Periodontitis; Serum, P < 0.0001 between Healthy and Periodontitis, P < 0.0001 between Gingivitis and Periodontitis). b Scatter plot of cfDNA levels and parameters of periodontal examination. The color of the dot represents the group of subjects. The dark blue line is the fitted regression line, and the light blue shading around it is the 95% confidence interval. c Heatmap of the Spearman’s correlation coefficient “r” between cfDNA levels in body fluids and parameters of periodontal examination. PLI: plaque index (1-3); BI: bleeding index (1-5); PD: probing depth (mm). “Mean” value is the arithmetic mean of the records of all examined sites. “(>n)%” is the percentage of site with parameter greater than “n” to the total number of sites. “Max” is the maximum of all sites.
