Fig. 7: IP6 is important for Integrator function.
From: Inositol hexakisphosphate is required for Integrator function
a Western blot analysis of DL1 cell lysates derived from cells treated with either control or IntS11 dsRNA. Rescues were conducted in cells depleted of IntS11 through the inducible expression of RNAi-resistant cDNA. b RT-qPCR analysis of selected genes identified to be upregulated upon IntS11 depletion using RNA-seq. Results are shown from biologically independent replicates, depicting averages and standard deviations (mean ± SD, n = 3). c Western blot analysis of DL1 cell lysates derived from cells treated with either control or IntS9 dsRNA. Rescues were conducted in cells depleted of IntS9 through the inducible expression of RNAi-resistant cDNA. trmt Drosophila IntS9 R504E/K508E/R209E triple mutant. d RT-qPCR analysis of selected genes identified to be upregulated upon IntS11 depletion using RNA-seq. Results are shown from biologically independent replicates, depicting averages and standard deviations (mean ± SD, n = 3). Source data are provided as a Source Data file.
