Fig. 2: Identification of conserved Fo subunits.
From: An ancestral interaction module promotes oligomerization in divergent mitochondrial ATP synthases
a Top view of the membrane region with T. brucei subunits (coloured) overlaid with S. cerevisiae structure (grey transparent). Close structural superposition and matching topology allowed the assignment of conserved subunits based on matching topology and location. b Superposition of subunits-b, -e and -g with their S. cerevisiae counterparts PDB 6B2Z (S. cerevisiae mitochondrial ATP synthase) confirms their identity. c Schematic representation of transmembrane helices of subunit-b and adjacent subunits in T. brucei, E. gracilis PDB 6TDV (E. gracilis mitochondrial ATP synthase, membrane region)10 and S. cerevisiae PDB 6B2Z (S. cerevisiae mitochondrial ATP synthase)7 ATP synthases. PC – phosphatidylcholine.
