Fig. 6: Properties of sample-level AP site hotspots in human cell lines treated with MMS. | Nature Communications

Fig. 6: Properties of sample-level AP site hotspots in human cell lines treated with MMS.

From: Complex genomic patterns of abasic sites in mammalian DNA revealed by a high-resolution SSiNGLe-AP method

Fig. 6

a Enrichment of hotspots in exons, introns and promoters in the samples treated with MMS (methyl methanesulfonate) and the corresponding controls in HeLa and K562 cell lines. b Enrichment of hotspots at SNPs and insertions in MMS-treated and control samples in HeLa and K562 cell lines. c Distribution of template vs. nontemplate ratios for hotspots in the exons and introns in the MMS-treated and control samples in the HeLa and K562 cell lines. a–c Hotspots were defined based on read depth ≥2. Asterisks above connecting lines indicate significance of difference between the MMS-treated and control samples as represented by raw p-values of ≤0.05 (*), ≤0.01 (**), ≤0.001 (***) and ≤0.0001 (****) calculated by the two-sided paired t test. Data are presented as mean values +/− SD based on three biological replicates. Source data are provided as a Source data file.

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