Fig. 7: Nucleotide distribution of all AP sites in the mouse nuclear genome.

a Average fractions of each nucleotide in the sequence of the nonrepeated portion of the mouse nuclear genome (“B”) as well as in all AP sites (“Depth ≥1”) or only hotspots (“Depth ≥2” or “Depth ≥3”) across the 71 samples. b Fraction of each nucleotide for all hotspots and those shared by the indicated number of samples. c Fraction of each nucleotide for all AP sites in different tissues (see Supplementary Fig. 8 for more information). Box plots indicate median (middle line), 25th, 75th percentile (box) and 1.5× interquartile range (whiskers) as well as each individual data (single points) based on 12 (3 biological replicates of 4 age groups) samples per tissue type with the exception of brain represented by 11 samples. Asterisks above connecting lines indicate the significance of differences between the indicated pairs of tissues as represented by raw p-values of ≤0.05 (*), ≤0.01 (**), ≤0.001 (***) and ≤0.0001 (****) calculated by the two-sided Wilcoxon rank-sum test. Source data are provided as a Source data file.