Fig. 8: Association of various genomic features of AP sites and age. | Nature Communications

Fig. 8: Association of various genomic features of AP sites and age.

From: Complex genomic patterns of abasic sites in mammalian DNA revealed by a high-resolution SSiNGLe-AP method

Fig. 8

a Spearman correlation (Y-axis) between global levels of AP sites (APF) and age in different tissues (X-axis). b Spearman correlation (X-axis) between age and fractions of sample-level hotspots with depth ≥2 across all tissues or in the individual tissues (Y-axis). c Spearman correlation (Y-axis) between age and the odds ratios of association of AP sites with different genomic elements in different tissues (X-axis). The dELS, pELS and PLS represent candidate cis-regulatory elements with distal enhancer-like, proximal enhancer-like and promoter signatures, respectively. d Spearman correlation (Y-axis) between age and nucleotide distribution of AP sites detected with the indicated read depths in different tissues (X-axis). The most consistent negative correlation pattern between age and fraction of AP sites at A nucleotides is highlighted. Source data are provided as a Source data file.

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