Fig. 9: Distribution of AP sites in the mouse mitochondrial genome.
a Distribution of AP sites in the D-loop region of the mouse mitochondrial genome. b Whole-chromosome view of the distribution of AP sites in the mitochondrial genome to show the dominance of the AP sites derived from the D-loop region (left). The view on the right represents the view with adjusted Y-axis and the D-loop region (with coordinated chrM: 15,650–15,900 bp) blocked by a gray box to show that the AP sites were also enriched on the minus (heavy) relative to the plus (light) strand of the genome outside of the D-loop region. The enrichment was further quantified in the histogram showing the fraction of AP sites mapping to the “+” or “−” strand in each tissue outside of the D-loop region. Data are presented as mean values +/− SD based on 12 (3 biological replicates of 4 age groups) samples per tissue type with the exception of brain represented by 11 samples. c Diagram of replication for the H (heavy) and L (light) strands of the mitochondrial genome (corresponding to the “−” and “+” strands, respectively) based on the commonly accepted strand displacement model42. The distribution of AP sites (Y-axes) is represented by the total number of reads corresponding to AP sites found at each nucleotide position across all 71 samples (a, b). Source data are provided as a Source data file.
