Fig. 2: The IURD phenotype structure, based on genetic correlation between phenotypes. | Nature Communications

Fig. 2: The IURD phenotype structure, based on genetic correlation between phenotypes.

From: Inflammatory and infectious upper respiratory diseases associate with 41 genomic loci and type 2 inflammation

Fig. 2

The boxes represent a GWAS of a IURD phenotype or group, stating the name, case count, and a number of MTS loci, indicating in parenthesis the MTS loci that were not detected in any directly preceding (“child”) GWAS. E.g., there were two loci in sinonasal disease GWAS that had not been detected in NSD, CISD, VAR, CRS, or NP GWASs. The hierarchical structure shows the phenotypes included in the parent phenotype. The IURD GWAS also included ICD codes J38 and J39 (not depicted); for these, no separate GWAS was performed. Sinonasal disease phenotypes (NSD, VAR, CRS, and NP) had a genetic correlation 78% or higher, as estimated using LD Score regression. Pharyngeal diseases (CDTA and PA) had a genetic correlation of 79%. The observed genetic correlations between chronic inflammatory sinonasal diseases (VAR, CRS, and NP) were 90% or higher.

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