Fig. 4: Glucose and infertility synergistically drive the lifespan of aged animals. | Nature Communications

Fig. 4: Glucose and infertility synergistically drive the lifespan of aged animals.

From: The unfolded protein response reverses the effects of glucose on lifespan in chemically-sterilized C. elegans

Fig. 4

a Cnetplots depict the linkages of genes and biological concepts in HGD-1 and HGD-5 compared to ND, respectively, where each nod shows the most enriched pathways. b-c Lifespan assays of WT (ND, n = 287; HGD-1, n = 255; HGD-5, n = 255 including biological replicates) (b) or fem-1(lof) hermaphrodite (ND, n = 186; HGD-1, n = 191; HGD-5, n = 209 including biological replicates) (c) animals fed normal diets (ND) or high glucose diet (HGD) from 1- (HGD-1) or 5-day old (HGD-5) in the absence of 5-Fluoro-2′-deoxyuridine (FUdR). d Lifespan assays of WT male animals fed ND, HGD-1, or HGD-5 in the absence of FUdR (ND, n = 150; HGD-1, n = 139; HGD-5, n = 143 including biological replicates). e Lifespan assays of WT hermaphrodite animals fed on ND, HGD-1, HGD-5 in the presence of FUdR from L4 to D8 (ND, n = 213; HGD-1, n = 216; HGD-5, n = 208 including biological replicates). Data shown are the mean ± SEM. Statistical analysis was subjected to log-rank test for lifespan.

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