Fig. 7: HGD-induced UPR modulates longevity differently in young and aged animals. | Nature Communications

Fig. 7: HGD-induced UPR modulates longevity differently in young and aged animals.

From: The unfolded protein response reverses the effects of glucose on lifespan in chemically-sterilized C. elegans

Fig. 7

C. elegans fed high glucose diet (HGD) at a young (day 1 of adulthood) or older (day 5 of adulthood) age induces a high and low metabolic imbalance, respectively. In turn, HGD reduces the longevity of young animals in an IRE-1-dependent manner while promoting an increase in lifespan via the ER stress sensors ATF-6 and PEK-1 in aged animals. The proposed model is applicable to chemically-sterilized worms. Created with BioRender.com.

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