Fig. 7: Schema summarizing key findings.
From: Functional and metabolic alterations of gut microbiota in children with new-onset type 1 diabetes
In-depth multi-omics analyses revealed a deteriorated gut microbial pattern of T1D involving butyrate metabolism, LPS biosynthesis, and bile acid metabolism. The combination of 18 bacteria species and fecal metabolites as gut biomarkers excellently discriminated T1D from controls. The animal experiments further unraveled that gut microflora of T1D was a causative factor in the regulation of glucose metabolism. Butyrate and lipopolysaccharide exerted protective and destructive effects, respectively, on islet structure and function in the T1D mouse model. Created with Biorender.com.
