Fig. 3: Effects of six potential causal proteins on stroke outcomes. | Nature Communications

Fig. 3: Effects of six potential causal proteins on stroke outcomes.

From: Systematic Mendelian randomization using the human plasma proteome to discover potential therapeutic targets for stroke

Fig. 3

MR analyses of the effect of proteins on stroke outcomes. The squares are the causal estimates on the OR scale, and the whiskers represent the 95% confidence intervals for these ORs. N_SNPs: number of SNPs used for the estimation of the causal effects in this plot. P values were determined from the inverse-variance-weighted two-sample MR method. Statistical heterogeneity was assessed using the I2 statistic. OR odds ratio, CD40 B cell surface antigen CD40, TFPI tissue factor pathway inhibitor, MMP12 matrix metallopeptidase 12, IL6RA interleukin 6 receptor subunit alpha, TMPRSS5 transmembrane serine protease 5, CD6 T-cell differentiation antigen CD6.

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