Fig. 5: Effect sizes (Z-score) of six potential causal proteins on stroke outcomes and causal risk factors for stroke. | Nature Communications

Fig. 5: Effect sizes (Z-score) of six potential causal proteins on stroke outcomes and causal risk factors for stroke.

From: Systematic Mendelian randomization using the human plasma proteome to discover potential therapeutic targets for stroke

Fig. 5

MR analyses of the effect of proteins on stroke and stroke risk factors. Colours in each lattice of the heatmap represent the effect size (Z-score), with genetically predicted increased protein level associated with a higher risk of outcomes coloured in brown and lower risk of outcomes coloured in blue. The darker the colour the larger the effect size. *Indicates that the causal association is significant, which passed Bonferroni correction of PcausalEstimate_IVW ≤ 0.05/308 = 1.61 × 10−4 and passed sensitivity tests with PQstat ≥ 0.05 and PEggerIntercept ≥ 0.05.

Back to article page