Fig. 6: Mediation effects of protein on stroke via risk factors. | Nature Communications

Fig. 6: Mediation effects of protein on stroke via risk factors.

From: Systematic Mendelian randomization using the human plasma proteome to discover potential therapeutic targets for stroke

Fig. 6

Mediation analyses to quantify the effects of three proteins on stroke outcomes via risk factors. a TFPI effect on stroke mediated by BMI. b TFPI effect on stroke mediated by WMH; c TMPRSS5 effect on cardioembolic stroke mediated by AF; d IL6RA effect on stroke mediated by AF. \({{{{{\rm{\beta }}}}}}\)EM effects of exposure on mediator, \({{{{{\rm{\beta }}}}}}\)MO effects of mediator on outcome, \({{{{{\rm{\beta }}}}}}\)EO effects of exposure on outcome. BMI body mass index, WMH white matter hyperintensity, AF atrial fibrillation.

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